Concerning our Lord Jesus Christ, we must also be aware that he is our Advocate, and that without him we cannot approach God.
By predestination we mean the eternal decree of God, by which he determined with himself whatever he wished to happen with regard to every man. (Inst. 3.21.5)
The predestination by which God adopts some to the hope of life, and adjudges others to eternal death, no man who would be thought pious ventures simply to deny; but it is greatly caviled at, especially by those who make prescience its cause. (Inst. 3.21.5)